The Positive Physical and Psychological Effects of ProArgi9 Plus: L-Arginine and Nitric Oxide


Proargi9+     Enhance Your Health With Synergy

We’ve known about the health benefits of nitric oxide for a long time, even before scientists were aware of its presence in the human body. Nitroglycerin, a drug that works on nitric oxide pathways, was adopted as a medical therapy for angina and high blood pressure in the 1880s, yet another century passed before we really understood how and why it worked.

The discovery of nitric oxide and its biological activities was so astounding that the 1998 Nobel Prize was awarded to the three pharmacologists who identified and furthered our understanding of this dynamic molecule and turned our understanding of the cause of cardiovascular disease upside down. Nitric Oxide performs a number of different tasks and has numerous benefits and I also want to explain how you can increase its production to improve numerous aspects of your own health.

Nitric Oxide’s Effects and Benefits
Nitric oxide is a key signalling molecule throughout the human body, without it we would die. It is produced by the endothelial cells lining the arteries, it penetrates the underlying smooth muscles and acts as a potent vasodilator that relaxes the arteries. Therefore, nitric oxide plays a critical role in blood pressure and overall circulation. It also keeps the endothelium in shape by curbing inflammation and oxidative stress.

Unfortunately, atherosclerosis, the underlying cause of heart disease and other vascular disorders, is characterised by endothelial dysfunction and a limited capacity to produce nitric oxide. It’s a vicious cycle. Diseased arteries can’t generate enough protective nitric oxide, and low nitric oxide levels set the stage for further damage, hypertension, and increased risk of cardiac events.

This explains why nitroglycerin is such an effective therapy for angina. It triggers nitric oxide production, which dilates narrowed coronary arteries, improving circulation and delivering much-needed oxygen to the heart muscle. Restoring nitric oxide availability also lowers blood pressure and helps treat erectile dysfunction. In fact, the popular erectile dysfunction drugs Viagra, Cialis, and Levitra work on nitric oxide pathways to increase blood flow to the penis and substantially improve erections.

How Nitric Oxide Helps
Additionally, this essential compound is generated in the brain, where it’s involved in neurotransmission. That’s why nitric oxide benefits also include protection against dementia and other neurodegenerative disorders. Nitric oxide is synthesised in the white blood cells as well and is used as a weapon against bacteria, fungi, parasites, and aberrant cancer cells.

In the gastrointestinal tract, it relaxes smooth muscle cells and helps regulate intestinal peristalsis and the secretion of mucus and gastric acid. Nitric oxide is also involved in insulin signalling, bone remodelling, respiratory function, ATP (energy) utilisation, and mitochondrial biogenesis, or the creation of new cellular “energy factories.” Since there are so many benefits of nitric oxide, it makes sense for all of us to boost our production of this essential compound.

Original source: http://www.drwhitaker.com/boost-nitric-oxide-levels-to-improve-health/

Goodbye Heart Disease, Diabetes and Strokes

The nitric oxide derived from L-Arginine is both directly and indirectly implicated in practically every cellular response and health condition imaginable, from the cardiovascular system to the immune system, and hormone function to nerve function. Although this is not an exhaustive list of possible applications for this amino acid, the following are the primary scientifically backed reasons that anyone, even healthy people, must consider adding L-Arginine to their health and wellness routine.

From a personal perspective, I have been taking ProArgi9 Plus for almost three years now and  began taking it as I had recently been diagnosed with a minor heart condition. Now almost three years on I hardly notice it at all, whereas previously it was very evident at numerous points through the day as my heart randomly tried to escape through my chest and caused shortness of breath and dizziness.

Also my father, who is now 70, has had heart trouble and been prescribed Warfarin etc and Statins. After about 12 months consistently taking ProArgi9 Plus he no longer requires Warfarin and has stopped taking the Statins. In combination with smaller food portions, healthier food, regular exercise of 20-30 minutes max, 5 times per week he is in better shape than he has been in quite a few years.

Proargi9+ & PDR

I am optimistic that the GMC will some day recognise the validity and efficacy of ProArgi9 Plus as has the AMA, because in the USA ProArgi9 Plus is the only non-pharmaceutical health supplement to be included in the Physicians Desk Reference (PDR) and GP’s there can prescribe it to their patients

  1. ProArgi9 Plus is one thousand times more powerful than any naturally occurring antioxidant in the body. L-Arginine`s antioxidant properties support various body systems and may protect against heart disease, stroke, cancer, and diabetes, as well as slowing premature ageing. [1, 2 ]
  2. ProArgi9 Plus offers wide-ranging cardiovascular support, including controlling blood pressure [3, 4] and plaque formation. Nitric oxide keeps arteries relaxed and pliable for normal blood pressure, preventing hypertension and angina. [5]
  3. ProArgi9 Plus enhances memory, [6] particularly long-term memory, and may help to reverse the effects of dementia and Alzheimer’s disease. [7]
  4. ProArgi9 Plus boosts human growth hormone (HGH) production, which has anti-ageing properties. [8]
  5. ProArgi9 Plus enhances communication of messenger cells between nerves and the brain. [9]
  6. ProArgi9 Plus may help improve immune function [10] and fight bacterial infections. [11]
  7. ProArgi9 Plus may help in the treatment and prevention of diabetes since many disease complications, including poor circulation and blindness, are vascular in nature. L-Arginine is also found to regulate insulin secretion in the pancreas. [12,13]
  8. ProArgi9 Plus may inhibit the division and proliferation of cancer cells. [14,15]
  9. ProArgi9 Plus helps with cholesterol control by lowering serum and LDL cholesterol levels. [16]
  10. ProArgi9 Plus enhances male sexual performance by treating vascular erectile dysfunction (ED). [17]
  11. ProArgi9 Plus anticoagulant abilities reduce clotting to lower heart attack and stroke risk. [18]
  12. ProArgi9 Plus reduces pregnancy-related hypertension, a risk factor for both the expecting mother and the unborn child. [19]
  13. ProArgi9 Plus is useful in the treatment of asthma by opening pulmonary pathways for easier breathing and the treatment of lung disorders. [20, 21]
  14. ProArgi9 Plus relaxes hypertonic sphincter muscles, preventing and healing haemorrhoids. [22]
  15. ProArgi9 Plus boosts lean muscle mass and preserves bone density by encouraging HGH production, [23] which also leads to a reduction in fatty tissue. Because of these properties, it may be useful in weight management and strength training.
  16. ProArgi9 Plus can help offset cardiovascular and lung damage caused by tobacco use,[24] since nitric oxide levels in smokers are less than half of those found in nonsmokers. [25]
  17. ProArgi9 Plus helps to accelerate wound healing [26] and post-surgery recovery. [27] Research has shown it is useful in treating burn wounds [28] and stimulates wound healing in the elderly. [29]
  18. ProArgi9 Plus may be useful in enhancing athletic performance due to its ability to boost exercise tolerance, [30] its beneficial effect on the lungs, and its effect on HGH levels. Which helps with building lean muscle tissue.
  19. ProArgi9 Plus may be used to improve the function of the prostate. [31]
  20. ProArgi9 Plus may prevent and possibly reverse the effects of osteoporosis by positively affecting bone mass. [32]
  21. ProArgi9 Plus has been used in the treatment of irritable bowel syndrome [33} and to reduce the occurrence of ulcers, particularly stress-related, without affecting gastric acid production. [34,35]
  22. ProArgi9 Plus may improve renal function and slow the progression of renal disease and age-related chronic renal failure. [36,37] Arginine`s protective effect on the kidneys may also benefit those with diabetes.

Source References:

  1. Kochupurackal P, et al. Nitric oxide: an antioxidant and neuro-protector. Annals of the New York Academy of Sciences. 2002; 962:389-401.
  2. Kumar CA, Das UN. Lipid peroxides, antioxidants and nitric oxide in patients with pre-eclampsia and essential hypertension. Med Sci-Monitor. 2000 Sep-Oct; 6(5):901-7.
  3. Brown, M.D., Dengel, D.R., Supiano, M.A. Nitric Oxide Biomarkers are Associated with the Blood Pressure-Lowering Effects of Dietary Sodium Restriction in Older Hypertensives. Circulation (Abstract I). 1997; 96:I-539.
  4. Rosano, G.M.C., Tanina, G., Cerquetani, E., Leonardo, F., Pelliccia, F., Bonfigli, B., and Chierchia, F.L. L-arginine Improves Endothelial Function in Newly Diagnosed Hypertensives. The Journal of the American College of Cardiology (Supplement A). 1998; 31:262a
  5. Moncada, F., Palmer, R.M.J., Higgs, E.A. The Discovery of Nitric Oxide as the Endogenous Nitro vasodilator. Hypertension. 1988; 12:365-72.
  6. Pautler EL. The possible role and treatment of deficient microcirculation regulation in age-associated memory impairment. Med Hypotheses. 1994 Jun; 42(6):363-6.
  7. Tarkowski E, et al. Intrathecal release of nitric oxide in Alzheimer’s disease and vascular dementia. Dement Geriatric Cogn Disord. 2000 Nov-Dec; 11(6):322-6.
  8. Ghigo E, Arvat E, Gianotti L, et al. Hypothalamic growth hormone-insulin-like growth facto-1 axis across the human life span. J Pediatr Endocrinol Metab.2000; 13 Suppl 6:1493-502.
  9. Fried R, Merrell WC. The Arginine Solution. New York, NY. Warner Books, 1999.
  10. Efron D, Barbul A. Role of arginine in immuno-nutrition. J Gastroentol. 2000; 35 Suppl 12:20-3..
  11. Korting GE, Smith SD, Wheeler MA, Weiss RM, Foster HE. A randomized double-blind study of oral L-arginine for treatment of interstitial cystitis. J Urol. 1999 Feb; 161(2):558-65.
  12. Piatti PM, Monti LD, Valsecchi G, et al. Long term oral L-arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetes. Diabetes Care. 2001 May; 24(5):875-80.
  13. Mohan IK, Cas UN. Effects of L-arginine-nitric oxide system on chemical induced diabetes mellitus. Free Radic Biol Med. 1998 Nov 1; 25(7):757-65.
  14. Heys SD, et al. Dietary supplementation with L-arginine: Modulation of tumour infiltrating lymphocytes in patients with colorectal cancer. Br J Surg. 1997 Feb; 84(2):238-41.
  15. Brittenden J, et al. Dietary supplementation with L-arginine in patients with breast cancer (> 4cm.) receiving multi-modality treatment: report of a feasibility study. Br J Cancer. 1994 May; 69(5):918-21.
  16. Khedara A, Kawai Y Kayashita J Kato N. Feeding rats the nitric oxide synthase inhibitor, L-N(omega) nitroarginine, elevates serum triglycerides and cholesterol and lowers hepatic fatty acid oxidation. J Nutr. 1996 Oct; 126(10):2563-7.
  17. Chen J, Wollman Y, Chernichovsky T, et al. Effect of high dose nitric oxide donor L-arginine in men with organic erectile dysfunction. BJU Int. 1999 Feb; 83(3):269-73.
  18. Wolf A, et al. Dietary L-arginine supplementation normalises platelet aggregation in hypercholesterolemic humans. J Am Coll Cardiol. 1997 Mar 1; 29(3):479.
  19. Podjarny, E., et al. Pregnancy-induced hypertension in rats with adriamycin nephropathy is associated with inadequate production of nitric oxide. Hypertension. 1997; 29:986-991.
  20. De Gouw HW, Verbruggen MB, Twiss IM, Sterk PJ. Effect of oral L-arginine on airway hyper-responsiveness to histamine in asthma. Thorax. 1999 Nov; 54(11):1033-5.
  21. De Gouw HW, Marshall-Partridge SJ, et al. Role of nitric oxide in the airway response to exercise in healthy and asthmatic subjects. J Appl Physiol. 2001 Feb; 90(2):586-92.
  22. Fried R, Merrell WC. The Arginine Solution. New York, New York. Warner Books, 1999. pp 4-5.
  23. Stevens BR, Godfrey MD, Kaminski TW, Braith RW. High intensity dynamic human muscle performance enhanced by a metabolic intervention. Med Sci Sports Exerc. 2000 Dec; 32(12):2102-8.
  24. Heitzer, T., Just, H., and Munzell, T. Antioxidant Vitamin C Improves Endothelium Function in Chronic Smokers. Circulation. 1996; 94:9.
  25. Zeiher, A.M., Schachinger, V., and Minners, J. Long-Term Cigarette Smoking Impairs Endothelium-Dependent Coronary Arterial Vasodilator Function. Circulation. 1995; 92:1094-1100.
  26. Barbul A, et al. Arginine enhances wound healing and lymphocyte immune responses in humans. Surgery. 1990 Aug; 108(2):331-6; discussion 336-7.
  27. Braga M, Gianotti L Raedelli G, et al. Perioperative immuno-nutrition in patients undergoing cancer surgery: results of a randomised double-blind phase 3 trial. Arch Surg. 1999 Apr; 134(4):428-33.
  28. De-Souza DA, Greene LJ. Pharmacological nutrition after burn injury. J of Nutri. 1998 May; 128(5):797-803.
  29. Kirk SJ, et al Arginine stimulates wound healing and immune function in elderly humans. Surgery. 1993 Aug; 114(2):155-9; discussion 160.
  30. Bednarz B, Wolk R, Chamiec T, et al. Effects of oral L-arginine supplementation on exercised induced QT dispersion and exercise tolerance in stable anginapectoris. Int J Cardiol. 2000 Sep 15; 75(2-3): 205-10.
  31. Aikawa K, Yokota T, et al. Endogenous nitric oxide-mediated relaxation and nitrinergic innervation in the rabbit prostate: the change with aging. Prostate. 2001 Jun 15; 48(1):40-6.
  32. Fini M, et al. Effect of l-lysine and L-arginine on primary osteoblast cultures from normal and osteopenic rats. Biomed Pharmacother. 2001 May; 55(4):213-21.
  33. Sahin AS, Atalik KE, Gunel E, Dogan N. Nonadrenergic, noncholinergic responses of the human colon smooth muscle and the role of K+channels in these responses. Methods Find Exp Clin Pharmacol. 2001 Jan-Feb; 23(1):13-7.
  34. Ohta Y, Nishida K., Protective effect of l-arginine against stress-induced gastric mucosal lesions in rats and its relation to nitric acid-mediated inhibition of neutrophil infiltration. Pharmacal Res. 2001 Jun; 43(6):535-41.
  35. Khattab MM, Gad MZ, Abdallah D. Protective role of nitric oxide in indo- methacin- induced gastric ulceration by a mechanism independent of gastric acid secretion. Pharmacol Res. 2001 May; 43(5):463-7.
  36. De Nicola L, Bellizzi V, Minutolo R, et al. Randomized, double-blind, placebo controlled study of arginine supplementation in chronic renal failure. Kidney Int. 1999 Aug; 56(2):674-84.
  37. Reckelhoff JF, et al. Long-term dietary supplementation with L-arginine prevents age related reduction in renal function. Am J Physiol. 1997 Jun; 272(6 Pt 2):1768-74.

Hypnosis and Allergies


Allergic reactions

Study 1: Hypnosis and Allergies – Skin Responses
Effect of hypnosis on allergic skin responses in asthma and hayfever.
http://www.bmj.com/highwire/filestream/228584/field_highwire_article_pdf/0/1145

Results: A significant diminution in the size of the weal was obtained in the hypnosis group at the lower two strengths of allergen. In the second part of the investigation, all participants were hypnotized and experienced a similar decrease.

Notes: Forty-seven subjects with known skin sensitivity to pollen and/or house-dust were divided into five groups and tested with four strengths of allergen. The prick-test method was employed. In the first part of the investigation a group of unhypnotized subjects were compared with a group who had suggestions made under hypnosis that their skin reactions to the allergen would not occur when tested a second time. In the second part of the investigation the subjects were divided into three groups. All were hypnotized, no suggestions regarding skin reactions were given to one group, the second group were given suggestions that only on one arm would the skin reactions be less or not recur, and in the third group the suggestion was made about the reactions on both arms. There was found to be a similar decrease in the response to prick-tests after hypnosis in all three groups.

Brit. Med. J. 1964:114S.1 148.
By: L. Fry, A. A. Mason, R. S. Pearson, Kings College Hospital, London

Study 2: Use of Hypnosis for Allergies Influenced by Psychological Events or Fear/Anxiety
Abreaction During Systematic Desensitization Under Hypnosis for Food Allergy [translated from Japanese].
http://ci.nii.ac.jp/naid/110001119115

Results: The authors of this paper state that it is well known that some food allergies are heavily influenced by psychological events and that fear and anxiety can play a role in this process. Then they describe the case of a 52-year-old woman who was admitted to hospital because of an allergic reaction caused by eating fish. She had only recently developed this allergy and when the authors of this study used hypnosis to uncover the cause, they found it was linked to the fear and anger she felt towards her ex-husband and her children’s attempt to get her to reconcile with him. After this fear and anger was released during hypnosis she no longer continued to have an allergy to fish.

Japanese Society of Psychosomatic Medicine 34(4); 329-333, 1994
By: I. Junko, M. Yoichi, A. Hiroyuki, T. Hideki, N. Tetsuya
Ishimoto Junko, Department of Psychosomatic Medicine, Faculty of Medicine, Kyushu University
Matsuoka Yoichi, Health Administration Center, University of the Ryukyus
Aoki Hiroyuki, Department of Psychosomatic Medicine, Kita-Kyushu Municipal Medical Center
Teshima Hideki, Department of Psychosomatic Medicine, Faculty of Medicine, Kyushu University
Nakagawa Tetsuya, Department of Studies on Life-Long Development and Education, Fukuoka Prefectural University

types-of-allergies

Study 3: Self-Hypnosis for Hay Fever

Effect of Self-Hypnosis on Hay Fever Symptoms – A Randomised Controlled Intervention Study.
http://bscw.rediris.es/pub/bscw.cgi/d4527335/Langewitz-Effect_self_hypnosis_hay_fever_symptoms.pdf

Results: After the first allergy season was over, the subjects using self-hypnosis reported that they experienced (on average) a 29.2 % reduction of their symptoms and a 26.2% improvement in their overall well-being, when compared to a control group. And while there were no further improvements between the first and second year of the study, the gains that were made the first year were maintained.

Notes: Seventy-nine subjects who were moderately to severely allergic to birch pollen and grass were taught how to practice self-hypnosis to decrease their allergic reactions and increase their feelings of well-being. The researchers managed to follow 52 of them over the next two years (or two complete allergy seasons).

Psychother Psychosom 2005;74:165-172
By: W. Langewitza, Division of Psychosomatic Medicine, Department of Internal Medicine
Jan Izakovicb, Allergy Unit, Department of Dermatology, University Hospital Basel
Jane Wylerc, Allergy Unit, Department of Dermatology, University Hospital BaseL
Christian Schindlerd, Institute of Social and Preventive Medicine, University of Basel, Basel, Switzerland

Study 4: Hypnotically Induced Analgesia for Flare Reactions
The Effect of Hypnotically Induced Analgesia on Flare Reaction of the Cutaneous Histamine Prick Test.
http://link.springer.com/article/10.1007/BF00371950#page-1

Results: Participants reported a 71.7% reduction in the pain during hypnosis. The researchers also noted that there was a significant reduction in the histamine flare area when the subject was hypnotized (as compared to the size of the histamine flare area that occurred in the pre and post hypnosis tests).

Notes: Ten highly hypnotizable subjects were recruited for this study. They were given a histamine prick test (which will cause a painful red welt to form on the skin) before, during and after a single hypnosis session (where they were given the hypnotic suggestion to experience analgesia in their arm). The subjects rated their feeling of pain on a visual analogue scale and reported a 71.7% reduction in the pain during hypnosis. The researchers also noted that there was a significant reduction in the histamine flare area when the subject was hypnotized (as compared to the size of the histamine flare area that occurred in the pre and post hypnosis tests).

Archives of Dermatological Research, Vol 282(8) Dec. 1990: 539-43
By: R. Zachariae, Institute of Psychology, University of Aarhus, Denmark
P. Bjerring, Dept. of Dermatology, Marselisborg Hospital, Denmark

Study 5: Hypnosis can Decrease or even Increase Allergic Skin Reactions
Increase and Decrease of Delayed Cutaneous Reactions Obtained By Hypnotic Suggestions During Sensitization Studies On Dinitrochlorobenzene and Diphenylcyclopropenone.
http://www.ncbi.nlm.nih.gov/pubmed/8457027

Results: The researchers found a significant difference in the allergic skin reaction between these two groups described below. Proving that hypnosis can both increase and decrease an allergic reaction.

Notes: Sixteen highly hypnotizable subjects were recruited to test how their skin reacted to two drugs (DNCB and DCP). They were randomly assigned to two groups. Using a combination of direct suggestion and guided imagery, hypnosis was used to heighten the immunological response to these drugs in one group and to reduce it in the other group. They were then sent them home and only brought back one month later for the actual skin-prick test.

Allergy Vol. 48(1):6-11
By: R. Zachariae, Institute of Psychology, University of Aarhus, Denmark
P. Bjerring, Dept. of Dermatology, Marselisborg Hospital, Denmark

Study 6: Hypnotizing a Person to Feel Sadness to Increase Allergic Reaction
Skin Reactions to Histamine of Healthy Subjects After Hypnotically Induced Emotions Of Sadness, Anger, and Happiness.
http://www.ncbi.nlm.nih.gov/pubmed/11488666

Results: The authors of this study begin by noting some of the anecdotal reports that claim emotions can increase allergic reactions. In an attempt to verify this, they recruited 15 highly hypnotizable subjects and gave them each a histamine prick test and then measured the size of the flare-up on the subject’s skin at specific intervals. They then repeated this after hypnotizing these subjects and inducing three emotions: sadness, happiness and anger. Happiness and anger did not cause any real changes. However, when they hypnotically induced feelings of sadness they found that there was a significant increase in the allergic reaction.

Allergy Vol. 56(8):734-740
By: R. Zachariae, Institute of Psychology, University of Aarhus, Denmark
M. M. Jørgensen, H. Egekvist, P. Bjerring, Dept. of Dermatology, Marselisborg Hospital, Denmark.